Meeting Excellence in Biomedicine: “Genomic keys of aging and longevity”


The Microcluster of VLC/CAMPUS Pathophysiology of Rare Diseases (MCIFER), within the framework of the Project of Excellence Meetings VLC/Campus, is organizing the conference closing the cycle commemorative 50th anniversary of the Spanish Society of Biochemistry and Molecular Biology (SEBBM).

In recent years, the extraordinary momentum of molecular biology has allowed the rigorous and thorough analysis of essential questions about the nature of life and human disease. Thus, the molecular scrutiny of aging and to extend the possibilities of life have begun to figure prominently in the group subjected to scientific problems place a new look. The human genome has 3,000 million nucleotides and about 25,000 genes that generate a harmonic universe of possible messages that make every moment of life in each of us. Why all this molecular harmony is lost and the cells are weakened, the tissues lose their functions, and the body ages, until finally surrenders? In his lecture, Professor Carlos Lopez-Otín present the recent work from his laboratory aimed at trying to provide answers to these questions.

Carlos López-Otín is Professor of Biochemistry and Molecular Biology in the Faculty of Medicine of the University of Oviedo. His professional work has also developed in the Ramón y Cajal Center and Center of Molecular Biology “Severo Ochoa” in Madrid, and the University of Lund in Sweden and New York and Harvard in the U.S. Currently, he combines teaching at the University of Oviedo with developing lines of research on cancer, aging and functional analysis of genomes. The group’s work has been directed to the identification of 60 novel human genes and analysis of their roles in tumor progression and other normal and pathological processes. He has also contributed to the annotation and characterization of the human genome and other organisms biomedical and evolutionary interest as the chimpanzee. Since 2010, he co-directs the Spanish contribution to the International Consortium of Cancer Genomes, who has deciphered the genome and the epigenome of hundreds of patients with chronic lymphocytic leukemia. Among the more recent work of his group include the discovery of anti – tumor proteases, the discovery of a new hereditary syndrome of accelerated aging, the development of a treatment for Hutchinson- Gilford progeria, the identification of two genes that slow cancer larynx and the definition of the molecular key to human aging. López – Otín teacher is a member of several academies and has won numerous awards, including the European FEBS worth noting Biochemistry Award, the Dupont Award in Life Sciences, the Echevarne Oncology Prize, the “Prize and Carmen Severo Ochoa” Molecular Biology, The Mexico Award Cobos Science and Technology Award for Biomedical Research, the Jaime I Research Award and the National Research Award “Santiago Ramón y Cajal”.

The Encounters of Excellence is an initiative of Campus International VLC/CAMPUS Excellence Program. Valencia, International Campus of Excellence, funded by the Ministry of Education, Culture and Sports. The aim of these annual programs is to encourage talent through conferences, meetings and dialogues with Nobel prizes and excellent scientists with research students in the areas of specialization of VLC/CAMPUS: Health, Sustainability and Information Technology and Communication.